Everything about Coenzyme M totally explained
Coenzyme M is a
coenzyme required for methyl-transfer reactions in the
metabolism of
methanogens. The coenzyme is an
anion with the formula HSCH
2CH
2SO
3-. It is named 2-mercaptoethanesulfonate and abbreviated HS-CoM. The
cation is unimportant, but the
sodium salt is most available. Mercaptoethanesulfonate contains both a
thiol, which is the main site of reactivity, and a
sulfonate group, which confers solubility in aqueous media.
Biochemical role
The coenzyme is the C1 carrier in
methanogenesis. It is converted to methyl coenzyme M, the
thioether CH
3SCH
2CH
2SO
3-, in the penultimate step to
methane formation. Coenzyme M reacts with
coenzyme B, 7-thioheptanoylthreoninephosphate, to give a heterodisulfide, releasing methane:
» CH
3-S-CoM + HS-CoB → CH
4 + CoB-S-S-CoM
This conversion is catalyzed by the
enzyme methyl coenzyme M reductase, which contains cofactor
F430 as the
prosthetic group.
Further Information
Get more info on 'Coenzyme M'.
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